The Human BioMolecular Research Institute (HBRI) is a 501(c)3 tax-exempt non-profit research institute doing basic research for the public good. HBRI was founded in December of 1997. The institute is located in the heart of biotech beach in a state-of-the-art 7,000 sq. ft. facility.

The research programs at HBRI are focused on unlocking biological and chemical principles related to diseases of the human body. Included in the areas of study are the use of stem cells to usher in new approaches to regenerative medicines for cardiovascular disease, neurological disease, cancer and bone diseases. Previous studies in Alzheimer’s disease and related neurodegenerative disorders, Parkinson’s disease, ALS, depression, neuroprotection, drug and alcohol abuse, pain and smoking cessation has resulted in numerous advances in medications development. The institute conducts fundamental studies of human disorders and translates findings into new drug development to address human illness. In addition, the institute promotes scientific learning through community service and public access by disseminating information and sharing research with collaborators, colleagues and the public.

“Where Medications Begin”


BREAKING NEWS: Small molecules that makes stem cells into heart cells.


San Diego, Calif., August 13, 2015 –Researchers at the Human BioMolecular Research Institute, the Sanford-Burnham-Prebys Medical Discovery Institute (Sanford-Burnham-Prebys), and ChemRegen, Inc. have created a small molecule that convert stem cells to heart cells. Published online on August 13th in Bioorganic and Medicinal Chemistry, the team describes how they synthesized and tested a novel class of 1,5-disubstituted benzimidazoles that can be used to generate unlimited numbers of new heart cells from stem cells.

“Because heart disease is the leading cause of death in this country we need to effectively replace lost heart muscle cells—called cardiomyocytes” said Mark Mercola, Ph.D., Director of Sanford-Burnham-Preby’s Muscle Development and Regeneration Program. “Using a small molecule to create new heart muscle cells from stem cells is very appealing.”

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