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Scientists
Use Dynamic Medicinal Chemistry to Help Cardiac Regeneration
FIGURE
Discovering
new medications for cardiovasular disease. Work of the Human
BioMolecular Research Institute in collaboration with the
Sanford-Burnham Medical Research Institute; John Cashman,
Ph.D. and Mark Mercola, Ph.D., respectively.
"Rat
neonatal cardiomyocytes stained for cell membrane (green)
and alpha actinin (red). CyteSeer from Vala Sciences was
used to identify sitesof alpha-actinin fluorescence.
Images
by Pat McDonough, Ph.D., at Vala Sciences and Fabio Cerignoli,
Ph.D., Sanford-Burnham Medical Research Institute.
Scientists
at the Human BioMolecular Research Institute (HBRI) in San
Diego, CA, and Sanford-Burnham Medical Research Institute
(Sanford-Burnham) in La Jolla, CA and ChemRegen, Inc., a
San Diego for-profit company focused on developing small-molecule
regenerative medicines for human diseases have reported
on a new set of small molecules helpful in human cardiomyocyte
formation using inhibition of a biochemical signaling pathway
called Wnt.
The
Wnt signaling pathway is a key mediator of cellular development
and stem cell differentiation. A paper published online*
in the Journal of Medicinal Chemistry reports a new class
of small molecules that work as Wnt inhibitors that can
be used to increase cardiogenesis from human stem cells.
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HERE to read the full press release.
CLICK
HERE to read more about the exciting work being done
by HBRI scientists.
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