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Scientists
Use Dynamic Medicinal Chemistry to Help Cardiac Regeneration
 FIGURE
Discovering
new medications for cardiovasular disease. Work of the Human
BioMolecular Research Institute in collaboration with the
Sanford-Burnham Medical Research Institute; John Cashman,
Ph.D. and Mark Mercola, Ph.D., respectively.
"Rat
neonatal cardiomyocytes stained for cell membrane (green)
and alpha actinin (red). CyteSeer from Vala Sciences was
used to identify sitesof alpha-actinin fluorescence.
Images
by Pat McDonough, Ph.D., at Vala Sciences and Fabio Cerignoli,
Ph.D., Sanford-Burnham Medical Research Institute.
Scientists
at the Human BioMolecular Research Institute (HBRI) in San
Diego, CA, and Sanford-Burnham Medical Research Institute
(Sanford-Burnham) in La Jolla, CA and ChemRegen, Inc., a
San Diego for-profit company focused on developing small-molecule
regenerative medicines for human diseases have reported
on a new set of small molecules helpful in human cardiomyocyte
formation using inhibition of a biochemical signaling pathway
called Wnt.
The
Wnt signaling pathway is a key mediator of cellular development
and stem cell differentiation. A paper published online*
in the Journal of Medicinal Chemistry reports a new class
of small molecules that work as Wnt inhibitors that can
be used to increase cardiogenesis from human stem cells.
CLICK
HERE to read the full press release.
CLICK
HERE to read more about the exciting work being done
by HBRI scientists.
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