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Contract
Research
HBRI engages
in contract research as a service to the scientific community
and to follow its mandate to do research in the interest of
the public. A wide variety of expertise in analytical chemistry,
synthetic and combinatorial medicinal chemistry, bioorganic
chemistry, biochemistry, molecular biology, cell biology and
vivarium work is available. In addition, considerable expertise
in drug design and drug development including safety evaluation
and in vitro and in vivo ADME studies are available. For inquiries
about contract work, contact the Director at JCashman@hbri.org
Contract Research Available:
HBRI has expertise in various areas of drug development and
drug safety evaluation available for contract work. Synthesis,
combinatorial chemistry, and synthesis of radiolabeled and
stably labeled compounds are available. Scale-up synthesis
is available. Analytical services including quantification
of pharmacokinetic or other pharmacologically relevant samples
by HPLC and GC are available. In vivo pharmacokinetic studies
of radiolabeled and non-radiolabeled compounds in small animals
is available.
In vitro drug safety evaluation of small molecules is available.
Determination of intrinsic clearance, microsomal half-life,
substrate-metabolic enzyme phenotyping, metabolic enzyme inhibition,
metabolic enzyme induction, protein binding, and metabolic
stability is available to predict drug safety in humans. Physical
pharmaceutical characterization including drug candidate stability,
solubility and lipophilicity is available.
Cloning, sequencing and cDNA-expression of target genes is
available. Biochemical characterization of novel enzymes and
receptors is available. cDNA-expression of human monooxygenases
including flavin-containing and cytochrome P-450 monooxygenases
is available. Cloning and cDNA-expression of novel esterases
is also available. Preparation of sub-cellular fractions from
animal and human for drug metabolism studies is available.
Biochemical and cellular characterization of neurotoxicity
in primary and cultured cells is available. Biochemical and
morphological evaluation of potentially apoptotic compounds
is available.
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