News
and Events
BREAKING NEWS: Scientists
Use Dynamic Medicinal Chemistry to Help
Cardiac Regeneration
San Diego,
Calif. (January 16, 2012) – Scientists at the Human
BioMolecular Research Institute (HBRI) in San Diego, CA,
and Sanford-Burnham Medical Research Institute (Sanford-Burnham)
in La Jolla, CA and ChemRegen, Inc., a San Diego for-profit
company focused on developing small-molecule regenerative
medicines for human diseases have reported on a new set
of small molecules helpful in human cardiomyocyte formation
using inhibition of a biochemical signaling pathway called
Wnt. The Wnt signaling pathway is a key mediator of cellular
development and stem cell differentiation. A paper published
online* in the Journal of Medicinal Chemistry reports a
new class of small molecules that work as Wnt inhibitors
that can be used to increase cardiogenesis from human stem
cells.
View
Press Release
Recent
News
San Diego,
Calif. (January 2012)
- Molecules To Protect The Brain From Nerve Gas
View
Press Release (pdf)
Link
to Article on C&EN
San Diego,
Calif. (July 2011)
- Scientists Use Chemical Biology Approach to Assist Cardiac
Regeneration
View
Press Release
San
Diego, Calif. (January 2011) - Scientists
Use Stem Cells to Heal Damaged Heart Tissue
View
Press Release
San
Diego, Calif. (October 2010)
- Scientists Develop Novel Research Tools for Detecting
Organophosphates
View
Press Release
San Diego,
Calif. (May 2010) - Scientists Study New Medications
for Depression
View
Press Release
San Diego,
Calif. (May 2010) - Scientists Study Phosphatase Enzyme
and Cancer
View
Press Release
San Diego,
Calif. (October
2009) - Scientists Study Model Compounds that Mimic
Neurodegenerative Agents
View
Press Release
San Diego,
Calif. (September 2009) - Scientists find new potential
antidote for cocaine drug abuse by studying cocaine intake
in rats
View
Press Release
San
Diego, Calif. (July 2009) -
Scientists Identify Cooperative Effects of Vitamin D and
Active Chemical in Curry that Stimulates the Immune System
to Clear Amyloid Plaques in Alzheimer’s Disease
View
Press Release
View
Full Article
San Diego,
Calif. (May 2009) -
Research
institute celebrates 10 years - View
Full Article
San Diego,
Calif. (March 2009) - Local 5th Grade Students Participate
in Annual Science Day at HBRI - View
Full Article
San Diego,
Calif. (January 2009) - Local Non-Profit Advancing
Diesease Research and Science Education - View
Full Article
Scientific
Publications
- ARCHIVE
Oligomerization of MBP-FMOs and kinetic comparison with
Supersome FMOs (September 2009) (Awaiting print).
Click
Here to Read Abstract
Chemical
Synthesis of Two Series of Nerve Agent Model Compounds and
Their Stereoselective Interaction with Human Acetylcholinesterase
and Human Butyrylcholinesterase (August
2009)
Nerve
Agent Analogues That Produce Authentic Soman, Sarin, Tabun,
and Cyclohexyl Methylphosphonate-Modified Human Butyrylcholinesterase
(August 2009)
Synthesis
and pharmacological evaluation of 6-naltrexamine analogs
for alcohol cessation (August 2009)
1a,25-dihydroxyvitamin
D_{3} Interacts with Curcuminoids to Stimulate Amyloid-ß
Clearance by Macrophages of Alzheimer's Disease Patients
(July 2009)
Novel
variants of the human flavin-containing monooxygenase 3
(FMO3) gene associated with trimethylaminuria. (June
2009)
Inhibition
of kappa opioid receptors attenuated increased cocaine intake
in rats with extended access to cocaine (May 2009)
Dual
inhibitors of phosphodiesterase-4 and serotonin reuptake.
(March 2009)
New
approach to treating CNS disorders, including depression
and memory.(March 2009) Click
here to read absract
Hepatic
flavin-containing monooxygenase gene regulation in different
mouse inflammation models. (March 2009)
Stereoselective
inhibition of serotonin re-uptake and phosphodiesterase
by dual inhibitors as potential agents for depression.
(January 2009)
Click
Here to View a comprehensive list of HBRI Publications
