Press Release

LATEST NEWS: Small molecules that makes stem cells into heart cells.


San Diego, Calif., August 13, 2015 – Researchers at the Human BioMolecular Research Institute, the Sanford-Burnham-Prebys Medical Discovery Institute (Sanford-Burnham-Prebys), and ChemRegen, Inc. have created a small molecule that convert stem cells to heart cells. Published online on August 13th in Bioorganic and Medicinal Chemistry, the team describes how they synthesized and tested a novel class of 1,5-disubstituted benzimidazoles that can be used to generate unlimited numbers of new heart cells from stem cells.

“Because heart disease is the leading cause of death in this country we need to effectively replace lost heart muscle cells—called cardiomyocytes” said Mark Mercola, Ph.D., Director of Sanford-Burnham-Preby’s Muscle Development and Regeneration Program. “Using a small molecule to create new heart muscle cells from stem cells is very appealing.”

CLICK HERE to read the full press release.
Link to Article in Bioorganic Medicinal Chemistry

Recent News

San Diego, Calif (August 13, 2015) – Novel Stereoselective Synthesis of Mexiletine Analogs
View Press Release
Link to Article in Tetrahedron Letters

San Diego, Calif. (November 14, 2012) – Small Molecule Makes Heart Cells out of Stem Cells
View Press Release
View Related Article Posted by the San Diego Union Tribune
New Chemical May Spur Heart Repair

San Diego, Calif. (December 21, 2012) – Antibodies to Detect Nerve Agents
View Press Release

San Francisco, Calif. (November 29, 2012) – “I have a dream…yes we scan”,
by Jeff Cavins, CEO of FuzeBox
View Press Release (pdf)

San Diego, Calif. (January 17, 2012) – Scientists Use Dynamic Medicinal Chemistry to Help Cardiac Regeneration
View Press Release (pdf)

San Diego, Calif. (January 2012) – Molecules To Protect The Brain From Nerve Gas
View Press Release (pdf)
Link to Article on C&EN

San Diego, Calif. (July 2011) – Scientists Use Chemical Biology Approach to Assist Cardiac Regeneration
View Press Release

San Diego, Calif. (January 2011) – Scientists Use Stem Cells to Heal Damaged Heart Tissue
View Press Release

San Diego, Calif. (October 2010) – Scientists Develop Novel Research Tools for Detecting Organophosphates
View Press Release

San Diego, Calif. (May 2010) – Scientists Study New Medications for Depression
View Press Release

San Diego, Calif. (May 2010) – Scientists Study Phosphatase Enzyme and Cancer
View Press Release




Characterization of Human Flavin-Containing Monooxygenase (FMO) 3 and FMO5 Expressed as Maltose-Binding Protein Fusions (December 2010).

Scientists Study Model Compounds that Mimic Neurodegenerative Agents (October 2009) Gilley, et al, 2009; Barakat, et al, 2009

Scientists find new potential antidote for cocaine drug abuse by studying cocaine intake in rats (September 2009) Wee, et al, 2009

Chemical Synthesis of Two Series of Nerve Agent Model Compounds and Their Stereoselective Interaction with Human Acetylcholinesterase and Human Butyrylcholinesterase (August 2009)

Nerve Agent Analogues That Produce Authentic Soman, Sarin, Tabun, and Cyclohexyl Methylphosphonate-Modified Human Butyrylcholinesterase (August 2009)

Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation (August 2009)

1a,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-ß Clearance by Macrophages of Alzheimer’s Disease Patients (July 2009)

Scientists Identify Cooperative Effects of Vitamin D and Active Chemical in Curry that Stimulates the Immune System to Clear Amyloid Plaques in Alzheimer’s Disease (July 2009)  Masoumi, et al, 2009

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria (June 2009)

Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine (May 2009)

Research Institute Celebrates 10 years (May 2009)

Dual inhibitors of phosphodiesterase-4 and serotonin reuptake (March 2009)

New approach to treating CNS disorders, including depression and memory(March 2009)

Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models (March 2009)

Local 5th Grade Students Participate in Annual Science Day at HBRI (March 2009)

Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression (January 2009)

Local Non-Profit Advancing Diesease Research and Science Education (January 2009)


Click Here to View Additional Scientific Publications by HBRI